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NEU1 Antibody

CAT: 0223-60-825Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-825Size:400 µL
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Background
The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein') . Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity.
NCBI Gene ID
4758
Swiss Prot
Q99519
Accession Number
Q99519
Host
Rabbit
Reactivity
Human
Immunogen
This NEU1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-214 amino acids from the Central region of human NEU1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
45 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NEU1
NCBI Official Name
Sialidase-1
NCBI Organism
Homo sapiens
Background Reference 01
Caciotti, A., et al. J. Neurol. 256 (11) :1911-1915 (2009)
Background Reference 02
Bonten, E.J., et al. J. Biol. Chem. 284 (41) :28430-28441 (2009)
Background Reference 03
Barcellos, L.F., et al. PLoS Genet. (10), E1000696 (2009) :
Background Reference 04
Wang, J., et al. J. Neurochem. 111 (2) :547-554 (2009)
Other Product Names
Sialidase-1, Acetylneuraminyl hydrolase, G9 sialidase, Lysosomal sialidase, N-acetyl-alpha-neuraminidase 1, NEU1, NANH
Tested Applications
WB
Protein ID
17368612
Physical Properties
Liquid

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