PDCD6IP Antibody

CAT: 0223-60-809Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-60-809Size:400 µL
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Background
This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
NCBI Gene ID
10015
Swiss Prot
Q8WUM4
Accession Number
Q8WUM4
Host
Rabbit
Reactivity
Human
Immunogen
This PDCD6IP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 541-570 amino acids from the Central region of human PDCD6IP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
96 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PDCD6IP
NCBI Official Name
Programmed cell death 6-interacting protein
NCBI Organism
Homo sapiens
Background Reference 01
Shi, X., et al. Biochem. J. 431 (1) :93-102 (2010)
Background Reference 02
Irie, T., et al. Virology 405 (2) :334-341 (2010)
Background Reference 03
Sette, P., et al. J. Virol. 84 (16) :8181-8192 (2010)
Background Reference 04
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Other Product Names
Programmed cell death 6-interacting protein, PDCD6-interacting protein, ALG-2-interacting protein 1, ALG-2-interacting protein X, Hp95, PDCD6IP, AIP1, ALIX, KIAA1375
Tested Applications
WB
Protein ID
31076831
Physical Properties
Liquid

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