PDCD6IP Antibody

• Background:

  This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

• NCBI Gene ID:

  10015

• Swiss Prot:

  Q8WUM4

• Accession Number:

  Q8WUM4

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PDCD6IP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 541-570 amino acids from the Central region of human PDCD6IP.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  96 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PDCD6IP

• NCBI Official Name:

  Programmed cell death 6-interacting protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Shi, X., et al. Biochem. J. 431 (1) :93-102 (2010)

• Background Reference 02:

  Irie, T., et al. Virology 405 (2) :334-341 (2010)

• Background Reference 03:

  Sette, P., et al. J. Virol. 84 (16) :8181-8192 (2010)

• Background Reference 04:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Other Product Names:

  Programmed cell death 6-interacting protein, PDCD6-interacting protein, ALG-2-interacting protein 1, ALG-2-interacting protein X, Hp95, PDCD6IP, AIP1, ALIX, KIAA1375

• Tested Applications:

  WB

• Protein ID:

  31076831

• Physical Properties:

  Liquid