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SH2D1A Antibody

CAT: 0223-60-808Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-808Size:400 µL
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Background
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
4068
Swiss Prot
O60880
Accession Number
O60880
Host
Rabbit
Reactivity
Human
Immunogen
This SH2D1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-114 amino acids from the C-terminal region of human SH2D1A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
14 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SH2D1A
NCBI Official Name
SH2 domain-containing protein 1A
NCBI Organism
Homo sapiens
Background Reference 01
Ameratunga, R., et al. N. Z. Med. J. 122 (1304) :46-53 (2009)
Background Reference 02
Snow, A.L., et al. J. Clin. Invest. 119 (10) :2976-2989 (2009)
Background Reference 03
Nagy, N., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (29) :11966-11971 (2009)
Background Reference 04
Ostrakhovitch, E.A., et al. Cell. Signal. 21 (4) :540-550 (2009)
Other Product Names
SH2 domain-containing protein 1A, Duncan disease SH2-protein, Signaling lymphocytic activation molecule-associated protein, SLAM-associated protein, T-cell signal transduction molecule SAP, SH2D1A, DSHP, SAP
Tested Applications
WB
Physical Properties
Liquid

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