Products for Research Use Only
RegisterLogin

LGMN Antibody

CAT: 0223-60-798Size: 400 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-60-798Size:400 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.
NCBI Gene ID
5641
Swiss Prot
Q99538
Accession Number
Q99538
Host
Rabbit
Reactivity
Human
Immunogen
This LGMN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-112 amino acids from the N-terminal region of human LGMN.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Immunology, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
49 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
LGMN
NCBI Official Name
Legumain
NCBI Organism
Homo sapiens
Background Reference 01
Clerin, V., et al. Atherosclerosis 201 (1) :53-66 (2008)
Background Reference 02
Liu, Z., et al. Mol. Cell 29 (6) :665-678 (2008)
Background Reference 03
Oh, J.H., et al. Mamm. Genome 16 (12) :942-954 (2005)
Background Reference 04
Dusso, A.S., et al. Am. J. Physiol. Renal Physiol. 289 (1), F8-F28 (2005) :
Other Product Names
Legumain, Asparaginyl endopeptidase, Protease, cysteine 1, LGMN, PRSC1
Tested Applications
WB
Protein ID
2842759
Physical Properties
Liquid

Related Products

CatalogName
64-160WAS Antibody
60-596WAS Antibody
13-349WAS Antibody
62-828Neprilysin Antibody
61-580CAPZB Antibody
55-580HCG_2024410 Antibody
30-580ACPT Antibody
19-580FABP3 Antibody
15-580POMGNT2 Antibody
35-153Cytomegalovirus Antibody

Alternative Products

CatalogName
C44517-01LGMN Antibody
STJ192484Anti-LGMN antibody
abx334421-01Legumain (LGMN) Antibody
RD265780A-01LGMN Polyclonal Antibody
567176-01LGMN

Popular Products