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RFWD2 Antibody

CAT: 0223-60-789Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-789Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1.
NCBI Gene ID
64326
Swiss Prot
Q8NHY2
Accession Number
Q8NHY2
Host
Rabbit
Reactivity
Human
Immunogen
This RFWD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 672-701 amino acids from the C-terminal region of human RFWD2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
80 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RFWD2
NCBI Official Name
E3 ubiquitin-protein ligase RFWD2
NCBI Organism
Homo sapiens
Background Reference 01
Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)
Background Reference 02
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 03
Kinyo, A., et al. J. Invest. Dermatol. 130 (2) :541-545 (2010)
Background Reference 04
Li, D.Q., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (41) :17493-17498 (2009)
Other Product Names
E3 ubiquitin-protein ligase RFWD2, 632-, Constitutive photomorphogenesis protein 1 homolog, hCOP1, RING finger and WD repeat domain protein 2, RING finger protein 200, RFWD2, COP1, RNF200
Tested Applications
WB
Protein ID
55976539
Physical Properties
Liquid

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