CASQ2 Antibody

• Background:

  The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. [provided by RefSeq].

• NCBI Gene ID:

  845

• Swiss Prot:

  O14958

• Accession Number:

  O14958

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CASQ2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-107 amino acids from the Central region of human CASQ2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rb

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  46 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CASQ2

• NCBI Official Name:

  Calsequestrin-2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kirchhefer, U., et al. J. Mol. Cell. Cardiol. 49 (1) :95-105 (2010)

• Background Reference 02:

  Wong, C.H., et al. Forensic Sci. Int. 192 (1-3), 53-55 (2009) :

• Background Reference 03:

  Liu, J., et al. Am. J. Physiol., Cell Physiol. 297 (1), C152-C159 (2009) :

• Background Reference 04:

  Hayashi, M., et al. Circulation 119 (18) :2426-2434 (2009)

• Other Product Names:

  Calsequestrin-2, Calsequestrin, cardiac muscle isoform, CASQ2

• Tested Applications:

  WB

• Physical Properties:

  Liquid