PDCD6 Antibody

• Background:

  This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant.

• NCBI Gene ID:

  10016

• Swiss Prot:

  O75340

• Accession Number:

  O75340

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PDCD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-47 amino acids from the N-terminal region of human PDCD6.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  22 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PDCD6

• NCBI Official Name:

  Programmed cell death protein 6

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Vergarajauregui, S., et al. J. Biol. Chem. 284 (52) :36357-36366 (2009)

• Background Reference 02:

  Okumura, M., et al. Biochem. Biophys. Res. Commun. 386 (1) :237-241 (2009)

• Background Reference 03:

  Suzuki, H., et al. Acta Crystallogr. Sect.Struct. Biol. Cryst. Commun. 64 (PT 11), 974-977 (2008) :

• Background Reference 04:

  Yamada, Y., et al. Cancer Sci. 99 (11) :2193-2199 (2008)

• Other Product Names:

  Programmed cell death protein 6, Apoptosis-linked gene 2 protein, Probable calcium-binding protein ALG-2, PDCD6, ALG2

• Tested Applications:

  WB

• Physical Properties:

  Liquid