PDCD5 Antibody

• Background:

  PDCD5 Antibody: Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis. The nucleotide polymorphisms in the 5'-upstream region of PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.

• NCBI Gene ID:

  9141

• Swiss Prot:

  O14737

• Accession Number:

  O14737.3

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  PDCD5 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1205 - Jurkat Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (100%)

• Buffer:

  PDCD5 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  PDCD5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  PDCD5

• Positive Control 2:

  Cat. No. 17-005 - Jurkat Cell Slide

• NCBI Official Name:

  Programmed cell death 5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Liu H, Wang Y, Zhang Y, et al. TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal. Biochem. Biophys. Res. Commun.1999; 254:203-10.

• Background Reference 02:

  Chen Y, Sun R, Han W, et al. Nuclear translocation of PDCD5 (TFAR19) : an early signal for apoptosis? FEBS Lett.2001; 509:191-6.

• Background Reference 03:

  Yao H, Xu L, Feng Y, et al. Structure-function correlation of human programmed cell death 5 protein. Arch. Biochem. Biophys.2009 Apr 7.

• Background Reference 04:

  Wang Y, Li X, Wang L, et al. An alternative form of paraptosis-like cell death triggered by TAJ/TROY and enhanced by PDCD5 overexpression. J. Cell Sci.2004; 117:1525-32.

• Other Product Names:

  PDCD5 Antibody: Programmed cell death protein 5, TF-1 cell apoptosis-related protein 19, TFAR19

• Tested Applications:

  ELISA, WB, ICC

• Protein ID:

  6226219

• Physical Properties:

  Liquid