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BLOC1S3 Antibody

CAT: 0223-60-771Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-771Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a protein that is a component of the BLOC1 multi-subunit protein complex. This complex is necessary for the biogenesis of specialized organelles of the endosomal-lysosomal system, including platelet dense granules and melanosomes. Mutations in this gene cause Hermansky-Pudlak syndrome 8, a disease characterized by lysosomal storage defects, bleeding due to platelet storage pool deficiency, and oculocutaneous albinism.
NCBI Gene ID
388552
Swiss Prot
Q6QNY0
Accession Number
Q6QNY0
Host
Rabbit
Reactivity
Human
Immunogen
This BLOC1S3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-202 amino acids from the C-terminal region of human BLOC1S3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
21 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
BLOC1S3
NCBI Official Name
Biogenesis of lysosome-related organelles complex 1 subunit 3
NCBI Organism
Homo sapiens
Background Reference 01
Seshadri, S., et al. JAMA 303 (18) :1832-1840 (2010)
Background Reference 02
Lowe, J.K., et al. PLoS Genet. (2), E1000365 (2009) :
Background Reference 03
Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)
Background Reference 04
Morgan, N.V., et al. Am. J. Hum. Genet. 78 (1) :160-166 (2006)
Other Product Names
Biogenesis of lysosome-related organelles complex 1 subunit 3, BLOC-1 subunit 3, BLOC1S3, BLOS3
Tested Applications
WB
Protein ID
74749299
Physical Properties
Liquid

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