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MYC Antibody

CAT: 0223-60-750Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-750Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of the gene encoding MYC have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
NCBI Gene ID
4609
Swiss Prot
P01106
Accession Number
P01106
Host
Rabbit
Reactivity
Human
Immunogen
This MYC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 351-380 amino acids from human MYC.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
49 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MYC
NCBI Official Name
Myc proto-oncogene protein
NCBI Organism
Homo sapiens
Background Reference 01
Lima, F.P., Am. J. Clin. Pathol. 129 (5), 723-726 (2008)
Background Reference 02
Ida, C., Biosci. Biotechnol. Biochem. 72 (3), 868-871 (2008)
Background Reference 03
Iijima, S., Eur. J. Biochem. 206 (2), 595-603 (1992)
Other Product Names
Myc proto-oncogene protein, Class E basic helix-loop-helix protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription factor p64, MYC, BHLHE39
Tested Applications
WB
Protein ID
127619
Physical Properties
Liquid

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