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PGR Antibody

CAT: 0223-60-738Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-738Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform A has not been clearly determined.
NCBI Gene ID
5241
Swiss Prot
P06401
Accession Number
P06401
Host
Rabbit
Reactivity
Human
Immunogen
This PGR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 523-550 amino acids from the Central region of human PGR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
99 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PGR
NCBI Official Name
Progesterone receptor
NCBI Organism
Homo sapiens
Background Reference 01
Geradts, J., et al. Cancer Invest. 28 (9) :969-977 (2010)
Background Reference 02
Tang, P., et al. Cancer Invest. 28 (9) :978-982 (2010)
Background Reference 03
Van Belle, V., et al. J. Clin. Oncol. 28 (27) :4129-4134 (2010)
Background Reference 04
Taylor, K.C., et al. Horm Res Paediatr (2010) In press :
Other Product Names
Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3, PGR, NR3C3
Tested Applications
WB
Protein ID
90110048
Physical Properties
Liquid

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