SUB1 Antibody

• Background:

  General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA) .

• NCBI Gene ID:

  10923

• Swiss Prot:

  P53999

• Accession Number:

  P53999

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SUB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-47 amino acids from the Central region of human SUB1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Monkey

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  14 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SUB1

• NCBI Official Name:

  Activated RNA polymerase II transcriptional coactivator p15

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Das, C., et al. J. Mol. Biol. 397 (1) :1-12 (2010)

• Background Reference 02:

  Rajagopalan, S., et al. J. Biol. Chem. 284 (32) :21728-21737 (2009)

• Background Reference 03:

  Mortusewicz, O., et al. J. Cell Biol. 183 (5) :769-776 (2008)

• Background Reference 04:

  Batta, K., et al. Mol. Cell. Biol. 27 (21) :7603-7614 (2007)

• Other Product Names:

  Activated RNA polymerase II transcriptional coactivator p15, Positive cofactor 4, PC4, SUB1 homolog, p14, SUB1, PC4, RPO2TC1

• Tested Applications:

  WB

• Protein ID:

  1709514

• Physical Properties:

  Liquid