NXT1 Antibody

• Background:

  The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein) - and CRM1 (required for chromosome region maintenance) -dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.

• NCBI Gene ID:

  29107

• Swiss Prot:

  Q9UKK6

• Accession Number:

  Q9UKK6

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This NXT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-111 amino acids from the C-terminal region of human NXT1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  16 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  NXT1

• NCBI Official Name:

  NTF2-related export protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Venkatesan, K., et al. Nat. Methods 6 (1) :83-90 (2009)

• Background Reference 02:

  Forler, D., et al. Nat. Biotechnol. 21 (1) :89-92 (2003)

• Background Reference 03:

  Katahira, J., et al. J. Biol. Chem. 277 (11) :9242-9246 (2002)

• Background Reference 04:

  Wiegand, H.L., et al. Mol. Cell. Biol. 22 (1) :245-256 (2002)

• Other Product Names:

  NTF2-related export protein 1, Protein p15, NXT1

• Tested Applications:

  WB

• Protein ID:

  18203504

• Physical Properties:

  Liquid