ASCL1 Antibody

• Background:

  This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3') . Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.

• NCBI Gene ID:

  429

• Swiss Prot:

  P50553

• Accession Number:

  P50553

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ASCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human ASCL1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  25 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ASCL1

• NCBI Official Name:

  Achaete-scute homolog 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Phi, J.H., et al.Neurosurg Pediatr 5 (6) :608-614 (2010)

• Background Reference 02:

  McGaughey, D.M., et al. Genomics 95 (6) :363-369 (2010)

• Background Reference 03:

  Li, F., et al. Zhongguo Fei Ai Za Zhi 13 (4) :317-321 (2010)

• Background Reference 04:

  Deng, H., et al. Biochem. Biophys. Res. Commun. 392 (4) :548-550 (2010)

• Other Product Names:

  Achaete-scute homolog 1, ASH-1, hASH1, Class A basic helix-loop-helix protein 46, bHLHa46, ASCL1, ASH1, BHLHA46, HASH1

• Tested Applications:

  WB

• Protein ID:

  20455478

• Physical Properties:

  Liquid