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ASCL1 Antibody

CAT: 0223-60-683Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-683Size:400 µL
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Background
This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3') . Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.
NCBI Gene ID
429
Swiss Prot
P50553
Accession Number
P50553
Host
Rabbit
Reactivity
Human
Immunogen
This ASCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human ASCL1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
25 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ASCL1
NCBI Official Name
Achaete-scute homolog 1
NCBI Organism
Homo sapiens
Background Reference 01
Phi, J.H., et al.Neurosurg Pediatr 5 (6) :608-614 (2010)
Background Reference 02
McGaughey, D.M., et al. Genomics 95 (6) :363-369 (2010)
Background Reference 03
Li, F., et al. Zhongguo Fei Ai Za Zhi 13 (4) :317-321 (2010)
Background Reference 04
Deng, H., et al. Biochem. Biophys. Res. Commun. 392 (4) :548-550 (2010)
Other Product Names
Achaete-scute homolog 1, ASH-1, hASH1, Class A basic helix-loop-helix protein 46, bHLHa46, ASCL1, ASH1, BHLHA46, HASH1
Tested Applications
WB
Protein ID
20455478
Physical Properties
Liquid

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