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XPC Antibody

CAT: 0223-60-674Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-674Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.
NCBI Gene ID
7508
Swiss Prot
Q01831
Accession Number
Q01831
Host
Rabbit
Reactivity
Human
Immunogen
This XPC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-183 amino acids from the N-terminal region of human XPC.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
106 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:2000
Symbol
XPC
NCBI Official Name
DNA repair protein complementing XP-C cells
NCBI Organism
Homo sapiens
Background Reference 01
Gangwar, R., et al. J. Cancer Res. Clin. Oncol. (2009) In press :
Background Reference 02
Agalliu, I., et al. Cancer Causes Control (2009) In press :
Background Reference 03
Langie, S.A., et al. Br. J. Nutr., 1-12 (2009) In press :
Background Reference 04
Young, R.P., et al. Postgrad Med85 (1008) :515-524 (2009)
Other Product Names
DNA repair protein complementing XP-C cells, Xeroderma pigmentosum group C-complementing protein, p125, XPC, XPCC
Tested Applications
WB
Protein ID
296453081
Physical Properties
Liquid

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