EBP Antibody

• Background:

  The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome) .

• NCBI Gene ID:

  10682

• Swiss Prot:

  Q15125

• Accession Number:

  Q15125

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This EBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 201-230 amino acids from the C-terminal region of human EBP.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  26 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  EBP

• NCBI Official Name:

  3-beta-hydroxysteroid-Delta (8), Delta (7) -isomerase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lu, Y., et al. J. Lipid Res. 49 (12) :2582-2589 (2008)

• Background Reference 02:

  Ausavarat, S., et al. EurDermatol 18 (4) :391-393 (2008)

• Background Reference 03:

  Steijlen, P.M., et al. Br. J. Dermatol. 157 (6) :1225-1229 (2007)

• Background Reference 04:

  Guggenberger, C., et al. J. Steroid Biochem. Mol. Biol. 104 (3-5), 105-109 (2007) :

• Other Product Names:

  3-beta-hydroxysteroid-Delta (8), Delta (7) -isomerase, Cholestenol Delta-isomerase, Delta (8) -Delta (7) sterol isomerase, D8-D7 sterol isomerase, Emopamil-binding protein, EBP

• Tested Applications:

  WB

• Protein ID:

  17374795

• Physical Properties:

  Liquid