EBP Antibody

CAT: 0223-60-650Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-60-650Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome) .
NCBI Gene ID
10682
Swiss Prot
Q15125
Accession Number
Q15125
Host
Rabbit
Reactivity
Human
Immunogen
This EBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 201-230 amino acids from the C-terminal region of human EBP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
26 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
EBP
NCBI Official Name
3-beta-hydroxysteroid-Delta (8), Delta (7) -isomerase
NCBI Organism
Homo sapiens
Background Reference 01
Lu, Y., et al. J. Lipid Res. 49 (12) :2582-2589 (2008)
Background Reference 02
Ausavarat, S., et al. EurDermatol 18 (4) :391-393 (2008)
Background Reference 03
Steijlen, P.M., et al. Br. J. Dermatol. 157 (6) :1225-1229 (2007)
Background Reference 04
Guggenberger, C., et al. J. Steroid Biochem. Mol. Biol. 104 (3-5), 105-109 (2007) :
Other Product Names
3-beta-hydroxysteroid-Delta (8), Delta (7) -isomerase, Cholestenol Delta-isomerase, Delta (8) -Delta (7) sterol isomerase, D8-D7 sterol isomerase, Emopamil-binding protein, EBP
Tested Applications
WB
Protein ID
17374795
Physical Properties
Liquid

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