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RMP Antibody

CAT: 0223-60-627Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-627Size:400 µL
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Background
The protein encoded by this gene binds to RNA polymerase II subunit 5 (RPB5) and negatively modulates transcription through its binding to RPB5. The encoded protein seems to have inhibitory effects on various types of activated transcription, but it requires the RPB5-binding region. This protein acts as a corepressor. It is suggested that it may require signaling processes for its function or that it negatively modulates genes in the chromatin structure. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
NCBI Gene ID
8725
Swiss Prot
O94763
Accession Number
O94763
Host
Rabbit
Reactivity
Human
Immunogen
This RMP (URI) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 347-376 amino acids from the C-terminal region of human RMP (URI) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
60 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
URI1
NCBI Official Name
Unconventional prefoldin RPB5 interactor 1
NCBI Organism
Homo sapiens
Background Reference 01
Delgermaa, L., et al., Mol. Cell. Biol. 24 (19) :8556-8566 (2004) .
Background Reference 02
Gstaiger, M., et al., Science 302 (5648) :1208-1212 (2003) .
Background Reference 03
Van Leuven, F., et al., Genomics 54 (3) :511-520 (1998) .
Background Reference 04
Dorjsuren, D., et al., Mol. Cell. Biol. 18 (12) :7546-7555 (1998) .
Other Product Names
Unconventional prefoldin RPB5 interactor 1, Protein NNX3, Protein phosphatase 1 regulatory subunit 19, RNA polymerase II subunit 5-mediating protein, RPB5-mediating protein, URI1, C19orf2, NNX3, PPP1R19, RMP, URI
Tested Applications
WB
Physical Properties
Liquid

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