BRMS1 Antibody

• Background:

  This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC) . The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.

• NCBI Gene ID:

  25855

• Swiss Prot:

  Q9HCU9

• Accession Number:

  Q9HCU9

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This BRMS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-77 amino acids from the N-terminal region of human BRMS1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  28 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  BRMS1

• NCBI Official Name:

  Breast cancer metastasis-suppressor 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Wu, Y., et al. Cancer Lett. 293 (1) :82-91 (2010)

• Background Reference 02:

  Vaidya, K.S., et al. Cancer Lett. 281 (1) :100-107 (2009)

• Background Reference 03:

  Frolova, N., et al. Tumour Biol. 30 (3) :148-159 (2009)

• Background Reference 04:

  Martins-de-Souza, D., et al. BMC Psychiatry 9, 17 (2009) :

• Other Product Names:

  Breast cancer metastasis-suppressor 1, BRMS1

• Tested Applications:

  WB

• Protein ID:

  18202959

• Physical Properties:

  Liquid