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SKP1 Antibody

CAT: 0223-60-508Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-508Size:400 µL
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Background
SKP1A is an F-box protein which functions as a substrate recognition component of the SCF ubiquitin ligase complex. It binds to cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins involved in ubiquitin proteolysis through an F-box motif. SKP1A also collaborates with a network of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor.
NCBI Gene ID
6500
Swiss Prot
P63208
Accession Number
P63208
Host
Rabbit
Reactivity
Human
Immunogen
This SKP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-87 amino acids from the Central region of human SKP1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Monkey, Mouse, Rat, Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
19 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SKP1
NCBI Official Name
S-phase kinase-associated protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Wu, G., et al., Mol. Cell 11 (6) :1445-1456 (2003) .
Background Reference 02
Piva, R., et al., Mol. Cell. Biol. 22 (23) :8375-8387 (2002) .
Background Reference 03
Matsuzawa, S.I., et al., Mol. Cell 7 (5) :915-926 (2001) .
Background Reference 04
Schulman, B.A., et al., Nature 408 (6810) :381-386 (2000) .
Other Product Names
S-phase kinase-associated protein 1, Cyclin-A/CDK2-associated protein p19, p19A, Organ of Corti protein 2, OCP-2, Organ of Corti protein II, OCP-II, RNA polymerase II elongation factor-like protein, SIII, Transcription elongation factor B polypeptide 1-like, p19skp1, SKP1, EMC19, OCP2, SKP1A, TCEB1L
Tested Applications
WB
Protein ID
52783797
Physical Properties
Liquid

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