DEFA3 Antibody

• Background:

  Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation.

• NCBI Gene ID:

  1668

• Swiss Prot:

  P59666

• Accession Number:

  P59666

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DEFA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-65 amino acids from the C-terminal region of human DEFA3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  10 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  DEFA3

• NCBI Official Name:

  Neutrophil defensin 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Han, S., et al. Hum. Immunol. 71 (7) :727-730 (2010)

• Background Reference 02:

  Chen, Q., et al. Anesthesiology 112 (6) :1428-1434 (2010)

• Background Reference 03:

  Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19 (5) :1356-1361 (2010)

• Background Reference 04:

  Paslakis, G., et al. Nephron Exp. Nephrol. 115 (4), E96-E100 (2010) :

• Other Product Names:

  Neutrophil defensin 3, Defensin, alpha 3, HNP-3, HP-3, HP3, HP 3-56, Neutrophil defensin 2, HNP-2, HP-2, HP2, DEFA3, DEF3

• Tested Applications:

  WB

• Protein ID:

  30316323

• Physical Properties:

  Liquid