TEF Antibody

CAT: 0223-60-382Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-60-382Size:400 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Thyrotroph embryonic factor (TEF), a transcription factor, is a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB) . Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP) ; VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
NCBI Gene ID
7008
Swiss Prot
Q10587
Accession Number
Q10587
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This TEF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 213-240 amino acids from the C-terminal region of human TEF.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Chicken, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
33 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TEF
NCBI Official Name
Thyrotroph embryonic factor
NCBI Organism
Homo sapiens
Background Reference 01
Kripke, D.F., et al. Psychiatry Investig 7 (1) :36-42 (2010)
Background Reference 02
Inukai, T., et al. Blood 105 (11) :4437-4444 (2005)
Background Reference 03
Collins, J.E., et al. Genome Biol. (10), R84 (2004) :
Background Reference 04
Newman, J.R., et al. Science 300 (5628) :2097-2101 (2003)
Other Product Names
Thyrotroph embryonic factor, TEF, KIAA1655
Tested Applications
WB
Protein ID
51338730
Physical Properties
Liquid

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