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BEST3 Antibody

CAT: 0223-60-376Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-376Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336) . Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]) .
NCBI Gene ID
144453
Swiss Prot
Q8N1M1
Accession Number
Q8N1M1
Host
Rabbit
Reactivity
Human
Immunogen
This BEST3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-68 amino acids from the N-terminal region of human BEST3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
76 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
BEST3
NCBI Official Name
Bestrophin-3
NCBI Organism
Homo sapiens
Background Reference 01
Marsey, L.L., et al. J. Physiol. (Lond.) 587 (PT 10), 2211-2224 (2009) :
Background Reference 02
Qu, Z.Q., et al. J. Biol. Chem. 282 (24) :17460-17467 (2007)
Background Reference 03
Tsunenari, T., et al. J. Biol. Chem. 278 (42) :41114-41125 (2003)
Background Reference 04
Stohr, H., et al. Eur. J. Hum. Genet. 10 (4) :281-284 (2002)
Other Product Names
Bestrophin-3, Vitelliform macular dystrophy 2-like protein 3, BEST3, VMD2L3
Tested Applications
WB
Protein ID
38503351
Physical Properties
Liquid

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