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DHH Antibody

CAT: 0223-60-360Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-360Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development.
NCBI Gene ID
50846
Swiss Prot
O43323
Accession Number
O43323
Host
Rabbit
Reactivity
Human
Immunogen
This DHH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the Central region of human DHH.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
DHH
NCBI Official Name
Desert hedgehog protein
NCBI Organism
Homo sapiens
Background Reference 01
Chinchilla, P., et al. Cell Cycle 9 (3) :570-579 (2010)
Background Reference 02
Bishop, B., et al. Nat. Struct. Mol. Biol. 16 (7) :698-703 (2009)
Background Reference 03
Hegde, G.V., et al. Mol. Cancer Res. 6 (12) :1928-1936 (2008)
Background Reference 04
Nakamura, M., et al. Fukuoka Igaku Zasshi 99 (5) :102-106 (2008)
Other Product Names
Desert hedgehog protein, DHH, HHG-3, Desert hedgehog protein N-product, Desert hedgehog protein C-product, DHH
Tested Applications
WB
Physical Properties
Liquid

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