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AKAP5 Antibody

CAT: 0223-60-359Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-359Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.
NCBI Gene ID
9495
Swiss Prot
P24588
Accession Number
P24588
Host
Rabbit
Reactivity
Human
Immunogen
This AKAP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the Central region of human AKAP5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
47 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
AKAP5
NCBI Official Name
A-kinase anchor protein 5
NCBI Organism
Homo sapiens
Background Reference 01
Willoughby, D., et al. J. Biol. Chem. 285 (26) :20328-20342 (2010)
Background Reference 02
Chen, M.H., et al. Cell. Signal. 21 (1) :136-142 (2009)
Background Reference 03
Tavalin, S.J. J. Biol. Chem. 283 (17) :11445-11452 (2008)
Background Reference 04
Correia, S.S., et al. Nat. Neurosci. 11 (4) :457-466 (2008)
Other Product Names
A-kinase anchor protein 5, AKAP-5, A-kinase anchor protein 79 kDa, AKAP 79, H21, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein, AKAP5, AKAP79
Tested Applications
WB
Protein ID
281185503
Physical Properties
Liquid

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