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AKAP4 Antibody

CAT: 0223-7961-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7961-01Size:0.02 mg
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Background
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell (1) . AKAP4, also known as hAKAP82, is a major sperm fibrous sheath protein that localizes to the entire length of the flagellum of human sperm (2) . It has been suggested that AKAP4 plays multiple roles in sperm motility and regulation of signal transduction pathways (2) . AKAP4 has also been postulated to be a potential biomarker for breast cancer (3) .
NCBI Gene ID
8852
Swiss Prot
Q5JQC9
Accession Number
NP_003877
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
AKAP4 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1313 - Human Testis Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (94%), Mouse: (88%)
Buffer
AKAP4 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
AKAP4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
AKAP4 antibody is human specific. At least three isoforms are known to exist; this antibody will detect the two longest isoforms.
Symbol
AKAP4
Positive Control 2
Cat. No. 11-701 - Human Testis Tissue Slide
NCBI Official Name
A kinase (PRKA) anchor protein 4
NCBI Organism
Homo sapiens
Background Reference 01
Carnegie GK, Means CK, and Scott JD. A-kinase anchoring proteins: from protein complexes to physiology and disease. IUBMB 2009; 61:394-406.
Background Reference 02
Turner RM, Johnson LR, Haig-Ladewig L, et al. An X-linked gene encodes a major human sperm fibrous sheath protein, hAKAP82. Genomic organization, protein kinase A-RII binding, and distribution of the precursor in the sperm tail. J. Biol. Chem. 1998; 273:32135-41.
Background Reference 03
Saini S, Jagadish N, Gupta A, et al. A novel cancer testis antigen, A-kinase anchor protein 4 (AKAP4) is a potential biomarker for breast cancer. PLoS One 2013; 8:e57095.
Other Product Names
A-kinase anchor protein 4, AKAP-4, AKAP82, hAKAP82, CT99, FSC1, HI, PRKA4
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
21493037
Physical Properties
Liquid

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