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NUP50 Antibody

CAT: 0223-60-337Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-337Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. NUP50 is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. NUP50 may serve as a binding site on the nuclear side of the pore complex for export receptor-cargo complexes. It interacts with multiple transport receptor proteins including p27Kip1. This interaction is required for correct intracellular transport and degradation of p27Kip1.
NCBI Gene ID
10762
Swiss Prot
Q9UKX7
Accession Number
Q9UKX7
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This NUP50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 432-461 amino acids from the C-terminal region of human NUP50.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
50 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NUP50
NCBI Official Name
Nuclear pore complex protein Nup50
NCBI Organism
Homo sapiens
Background Reference 01
Lindsay, M.E., et al., Cell 110 (3) :349-360 (2002) .
Background Reference 02
Swaminathan, S., et al., Dev. Cell 3 (3) :304-306 (2002) .
Background Reference 03
Smitherman, M., et al., Mol. Cell. Biol. 20 (15) :5631-5642 (2000) .
Background Reference 04
Guan, T., et al., Mol. Cell. Biol. 20 (15) :5619-5630 (2000) .
Other Product Names
Nuclear pore complex protein Nup50, 50 kDa nucleoporin, Nuclear pore-associated protein 60 kDa-like, Nucleoporin Nup50, NUP50, NPAP60L
Tested Applications
WB
Protein ID
20455193
Physical Properties
Liquid

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