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TSEN2 Antibody

CAT: 0223-60-318Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-318Size:400 µL
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Background
This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
80746
Swiss Prot
Q8NCE0
Accession Number
Q8NCE0
Host
Rabbit
Reactivity
Human
Immunogen
This TSEN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-43 amino acids from the N-terminal region of human TSEN2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
53 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TSEN2
NCBI Official Name
TRNA-splicing endonuclease subunit Sen2
NCBI Organism
Homo sapiens
Background Reference 01
Weitzer, S., et al. Nature 447 (7141) :222-226 (2007)
Background Reference 02
Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)
Background Reference 03
Ballif, B.A., et al. Mol. Cell Proteomics 3 (11) :1093-1101 (2004)
Background Reference 04
Paushkin, S.V., et al. Cell 117 (3) :311-321 (2004)
Other Product Names
TRNA-splicing endonuclease subunit Sen2, tRNA-intron endonuclease Sen2, HsSen2, TSEN2, SEN2
Tested Applications
WB
Protein ID
50428914
Physical Properties
Liquid

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