SPANXE Antibody

• Background :

  Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that contains a consensus nuclear localization signal but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined.

• NCBI Gene ID :

  64663

• Swiss Prot :

  Q8TAD1

• Accession Number :

  Q8TAD1

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This SPANXE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-65 amino acids from the Central region of human SPANXE.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  11 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  SPANXE

• NCBI Official Name :

  Sperm protein associated with the nucleus on the X chromosome E

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Hansen, S., et al. Syst Biol Reprod Med 55, 18-26 (2010) :

• Background Reference 02 :

  Kouprina, N., et al. Genome Res. 15 (11) :1477-1486 (2005)

• Background Reference 03 :

  Zendman, A.J., et al. Gene 309 (2) :125-133 (2003)

• Background Reference 04 :

  Westbrook, V.A., et al. Biol. Reprod. 64 (1) :345-358 (2001)

• Other Product Names :

  Sperm protein associated with the nucleus on the X chromosome E, Nuclear-associated protein SPAN-Xe, SPANX-E, SPANX family member E, SPANXE

• Tested Applications :

  WB

• Protein ID :

  85543354

• Physical Properties :

  Liquid