TULP3 Antibody

• Background:

  This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene.

• NCBI Gene ID:

  7289

• Swiss Prot:

  O75386

• Accession Number:

  O75386

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TULP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374-400 amino acids from the C-terminal region of human TULP3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  50 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  TULP3

• NCBI Official Name:

  Tubby-related protein 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :

• Background Reference 02:

  Ikeda, A., et al. J. Cell. Sci. 115 (PT 1), 9-14 (2002) :

• Background Reference 03:

  Santagata, S., et al. Science 292 (5524) :2041-2050 (2001)

• Background Reference 04:

  Ikeda, S., et al. Invest. Ophthalmol. Vis. Sci. 40 (11) :2706-2712 (1999)

• Other Product Names:

  Tubby-related protein 3, Tubby-like protein 3, TULP3, TUBL3

• Tested Applications:

  WB

• Physical Properties:

  Liquid