TULP3 Antibody

CAT: 0223-60-269Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-60-269Size:400 µL
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Background
This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene.
NCBI Gene ID
7289
Swiss Prot
O75386
Accession Number
O75386
Host
Rabbit
Reactivity
Human
Immunogen
This TULP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374-400 amino acids from the C-terminal region of human TULP3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
50 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TULP3
NCBI Official Name
Tubby-related protein 3
NCBI Organism
Homo sapiens
Background Reference 01
Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :
Background Reference 02
Ikeda, A., et al. J. Cell. Sci. 115 (PT 1), 9-14 (2002) :
Background Reference 03
Santagata, S., et al. Science 292 (5524) :2041-2050 (2001)
Background Reference 04
Ikeda, S., et al. Invest. Ophthalmol. Vis. Sci. 40 (11) :2706-2712 (1999)
Other Product Names
Tubby-related protein 3, Tubby-like protein 3, TULP3, TUBL3
Tested Applications
WB
Physical Properties
Liquid

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