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OSCAR Antibody

CAT: 0223-60-164Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-164Size:400 µL
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Background
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
126014
Swiss Prot
Q8IYS5
Accession Number
Q8IYS5
Host
Rabbit
Reactivity
Human
Immunogen
This OSCAR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-231 amino acids from the C-terminal region of human OSCAR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
30 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
OSCAR
NCBI Official Name
Osteoclast-associated immunoglobulin-like receptor
NCBI Organism
Homo sapiens
Background Reference 01
Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)
Background Reference 02
Yerges, L.M., et al. J. Bone Miner. Res. 24 (12) :2039-2049 (2009)
Background Reference 03
Herman, S., et al. Arthritis Rheum. 58 (10) :3041-3050 (2008)
Background Reference 04
Merck, E., et al. J. Immunol. 176 (5) :3149-3156 (2006)
Other Product Names
Osteoclast-associated immunoglobulin-like receptor, Osteoclast-associated receptor, hOSCAR, Polymeric immunoglobulin receptor 3, PIgR-3, PIgR3, Poly-Ig receptor 3, OSCAR
Tested Applications
WB
Protein ID
311033418
Physical Properties
Liquid

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