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LCP1 Antibody

CAT: 0223-60-157Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-157Size:400 µL
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Background
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.) . However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.
NCBI Gene ID
3936
Swiss Prot
P13796
Accession Number
P13796
Host
Rabbit
Reactivity
Human
Immunogen
This LCP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-335 amino acids from the Central region of human LCP1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
70 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
LCP1
NCBI Official Name
Plastin-2
NCBI Organism
Homo sapiens
Background Reference 01
Wabnitz, G.H., et al. Eur. J. Immunol. 40 (9) :2437-2449 (2010)
Background Reference 02
Janji, B., et al. J. Cell. Mol. Med. 14 (6A), 1264-1275 (2010) :
Background Reference 03
Le Goff, E., et al. Cytoskeleton (Hoboken) 67 (5) :286-296 (2010)
Background Reference 04
Al Tanoury, Z., et al. PLoS ONE (2), E9210 (2010) :
Other Product Names
Plastin-2, L-plastin, LC64P, Lymphocyte cytosolic protein 1, LCP-1, LCP1, PLS2
Tested Applications
WB
Protein ID
308153685
Physical Properties
Liquid

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