SKAP1 Antibody

• Background:

  This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.

• NCBI Gene ID:

  8631

• Swiss Prot:

  Q86WV1

• Accession Number:

  Q86WV1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SKAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-295 amino acids from the C-terminal region of human SKAP1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  41 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SKAP1

• NCBI Official Name:

  Src kinase-associated phosphoprotein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Goode, E.L., et al. Nat. Genet. 42 (10) :874-879 (2010)

• Background Reference 02:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 03:

  Raab, M., et al. Immunity 32 (4) :541-556 (2010)

• Background Reference 04:

  Lehmann, R., et al. Proteomics 9 (23) :5288-5295 (2009)

• Other Product Names:

  Src kinase-associated phosphoprotein 1, Src family-associated phosphoprotein 1, Src kinase-associated phosphoprotein of 55 kDa, SKAP-55, pp55, SKAP1, SCAP1, SKAP55

• Tested Applications:

  WB

• Protein ID:

  269849660

• Physical Properties:

  Liquid