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CRYGD Antibody

CAT: 0223-60-145Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-145Size:400 µL
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Background
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.
NCBI Gene ID
1421
Swiss Prot
P07320
Accession Number
P07320
Host
Rabbit
Reactivity
Human
Immunogen
This CRYGD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-101 amino acids from the Central region of human CRYGD.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
21 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CRYGD
NCBI Official Name
Gamma-crystallin D
NCBI Organism
Homo sapiens
Background Reference 01
Acosta-Sampson, L., et al. J. Mol. Biol. 401 (1) :134-152 (2010)
Background Reference 02
Wang, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (30) :13282-13287 (2010)
Background Reference 03
Pande, A., et al. Biochemistry 49 (29) :6122-6129 (2010)
Background Reference 04
Das, P., et al. Protein Sci. 19 (1) :131-140 (2010)
Other Product Names
Gamma-crystallin D, Gamma-D-crystallin, Gamma-crystallin 4, CRYGD, CRYG4
Tested Applications
WB
Protein ID
2506321
Physical Properties
Liquid

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