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FBXO8 Antibody

CAT: 0223-60-087Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-087Size:400 µL
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Background
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor (s) (ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity.
NCBI Gene ID
26269
Swiss Prot
Q9NRD0
Accession Number
Q9NRD0
Host
Rabbit
Reactivity
Mouse
Immunogen
This FBXO8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-195 amino acids from the Central region of human FBXO8.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
37 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
FBXO8
NCBI Official Name
F-box only protein 8
NCBI Organism
Homo sapiens
Background Reference 01
Cronin, S., et al. Eur. J. Hum. Genet. 17 (2) :213-218 (2009)
Background Reference 02
Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)
Background Reference 03
Clark, H.F., et al. Genome Res. 13 (10) :2265-2270 (2003)
Background Reference 04
Ilyin, G.P., et al. Genomics 67 (1) :40-47 (2000)
Other Product Names
F-box only protein 8, F-box/SEC7 protein FBS, FBXO8, FBS, FBX8
Tested Applications
WB
Protein ID
13124142
Physical Properties
Liquid

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