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TAPBP Antibody

CAT: 0223-60-069Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-069Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.
NCBI Gene ID
6892
Swiss Prot
O15533
Accession Number
O15533
Host
Rabbit
Reactivity
Human
Immunogen
This TAPBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the N-terminal region of human TAPBP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
48 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TAPBP
NCBI Official Name
Tapasin
NCBI Organism
Homo sapiens
Background Reference 01
Jiang, Q., et al. Tumour Biol. 31 (5) :451-459 (2010)
Background Reference 02
Rizvi, S.M., et al. Traffic 11 (3) :332-347 (2010)
Background Reference 03
Praveen, P.V., et al. Eur. J. Immunol. 40 (1) :214-224 (2010)
Background Reference 04
Barcellos, L.F., et al. PLoS Genet. (10), E1000696 (2009) :
Other Product Names
Tapasin, TPN, TPSN, NGS-17, TAP-associated protein, TAP-binding protein, TAPBP, NGS17, TAPA
Tested Applications
WB
Physical Properties
Liquid

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