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ACER1 Antibody

CAT: 0223-60-034Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-034Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]) .
NCBI Gene ID
125981
Swiss Prot
Q8TDN7
Accession Number
Q8TDN7
Host
Rabbit
Reactivity
Human
Immunogen
This ACER1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-263 amino acids from the C-terminal region of human ACER1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
31 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ACER1
NCBI Official Name
Alkaline ceramidase 1
NCBI Organism
Homo sapiens
Background Reference 01
Sun, W., et al. J. Invest. Dermatol. 128 (2) :389-397 (2008)
Background Reference 02
Toulza, E., et al. Genome Biol. (6), R107 (2007) :
Background Reference 03
Houben, E., et al. J. Lipid Res. 47 (5) :1063-1070 (2006)
Background Reference 04
Mao, C., et al. J. Biol. Chem. 278 (33) :31184-31191 (2003)
Other Product Names
Alkaline ceramidase 1, AlkCDase 1, Alkaline CDase 1, Acylsphingosine deacylase 3, N-acylsphingosine amidohydrolase 3, ACER1, ASAH3
Tested Applications
WB
Protein ID
74715919
Physical Properties
Liquid

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