MRPL40 Antibody

• Background:

  Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome.

• NCBI Gene ID:

  64976

• Swiss Prot:

  Q9NQ50

• Accession Number:

  Q9NQ50

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MRPL40 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-200 amino acids from the C-terminal region of human MRPL40.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  24 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  MRPL40

• NCBI Official Name:

  39S ribosomal protein L40, mitochondrial

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Collins, J.E., et al. Genome Biol. (10), R84 (2004) :

• Background Reference 02:

  Zhang, Z., et al. Genomics 81 (5) :468-480 (2003)

• Background Reference 03:

  Kenmochi, N., et al. Genomics 77 (1-2), 65-70 (2001) :

• Background Reference 04:

  Hildebrandt, T., et al. Anticancer Res. 19 (1A), 525-530 (1999) :

• Other Product Names:

  39S ribosomal protein L40, mitochondrial, L40mt, MRP-L40, Nuclear localization signal-containing protein deleted in velocardiofacial syndrome, Up-regulated in metastasis, MRPL40, NLVCF, URIM

• Tested Applications:

  WB

• Protein ID:

  21263795

• Physical Properties:

  Liquid