AMOT Antibody

• Background:

  This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.

• NCBI Gene ID:

  154796

• Swiss Prot:

  Q4VCS5

• Accession Number:

  Q4VCS5

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This AMOT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 240-267 amino acids from the N-terminal region of human AMOT.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  118 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  AMOT

• NCBI Official Name:

  Angiomotin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Heller, B., et al. J. Biol. Chem. 285 (16) :12308-12320 (2010)

• Background Reference 03:

  Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)

• Background Reference 04:

  Gagne, V., et al. Cell Motil. Cytoskeleton 66 (9) :754-768 (2009)

• Other Product Names:

  Angiomotin, AMOT, KIAA1071

• Tested Applications:

  WB

• Protein ID:

  74753814

• Physical Properties:

  Liquid