CHMP5 Antibody

• Background:

  CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs) . Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]) .

• NCBI Gene ID:

  51510

• Swiss Prot:

  Q9NZZ3

• Accession Number:

  Q9NZZ3

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CHMP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 178-204 amino acids from the C-terminal region of human CHMP5.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  25 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CHMP5

• NCBI Official Name:

  Charged multivesicular body protein 5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Wang, H.R., et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 16 (2) :282-285 (2008)

• Background Reference 02:

  Row, P.E., et al. J. Biol. Chem. 282 (42) :30929-30937 (2007)

• Background Reference 03:

  Huang, H.H., et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 15 (4) :738-742 (2007)

• Background Reference 04:

  Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

• Other Product Names:

  Charged multivesicular body protein 5, Chromatin-modifying protein 5, SNF7 domain-containing protein 2, Vacuolar protein sorting-associated protein 60, Vps60, hVps60, CHMP5, C9orf83, SNF7DC2

• Tested Applications:

  WB

• Protein ID:

  51702157

• Physical Properties:

  Liquid