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PPP4R2 Antibody

CAT: 0223-59-916Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-916Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4) . May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.
NCBI Gene ID
151987
Swiss Prot
Q9NY27
Accession Number
Q9NY27
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This PPP4R2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-254 amino acids from the Central region of human PPP4R2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
47 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PPP4R2
NCBI Official Name
Serine/threonine-protein phosphatase 4 regulatory subunit 2
NCBI Organism
Homo sapiens
Background Reference 01
Lee, D.H., et al. Nat. Struct. Mol. Biol. 17 (3) :365-372 (2010)
Background Reference 02
Chen, G.I., et al. J. Biol. Chem. 283 (43) :29273-29284 (2008)
Background Reference 03
Chowdhury, D., et al. Mol. Cell 31 (1) :33-46 (2008)
Background Reference 04
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Other Product Names
Serine/threonine-protein phosphatase 4 regulatory subunit 2, PPP4R2
Tested Applications
WB
Protein ID
158564082
Physical Properties
Liquid

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