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GCLC Antibody

CAT: 0223-59-915Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-915Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
NCBI Gene ID
2729
Swiss Prot
P48506
Accession Number
P48506
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This GCLC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-315 amino acids from the Central region of human GCLC.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
73 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
GCLC
NCBI Official Name
Glutamate--cysteine ligase catalytic subunit
NCBI Organism
Homo sapiens
Background Reference 01
Man, B.L., et al.Clin Neurosci 17 (10) :1244-1247 (2010)
Background Reference 02
Jia, P., et al. Schizophr. Res. 122 (1-3), 38-42 (2010) :
Background Reference 03
Le, T.M., et al. Mol. Genet. Metab. 101 (1) :55-61 (2010)
Background Reference 04
Fullerton, J.M., et al. Bipolar Disord 12 (5) :550-556 (2010)
Other Product Names
Glutamate--cysteine ligase catalytic subunit, GCS heavy chain, Gamma-ECS, Gamma-glutamylcysteine synthetase, GCLC, GLCL, GLCLC
Tested Applications
WB
Protein ID
1346190
Physical Properties
Liquid

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