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VDR Antibody

CAT: 0223-59-872Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-872Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.
NCBI Gene ID
7421
Swiss Prot
P11473
Accession Number
P11473
Host
Rabbit
Reactivity
Human
Immunogen
This VDR antibody is generated from rabbits immunized with a recombinant protein of human VDR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
48 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
VDR
NCBI Official Name
Vitamin D3 receptor
NCBI Organism
Homo sapiens
Background Reference 01
An, B.S., et al. Mol. Cell. Biol. 30 (20) :4890-4900 (2010)
Background Reference 02
Elnenaei, M.O., et al. Br. J. Nutr., 1-8 (2010) In press :
Background Reference 03
Forghani, N., et al. J. Pediatr. Endocrinol. Metab. 23 (8) :843-850 (2010)
Background Reference 04
Alvarez-Nava, F., et al. J. Pediatr. Endocrinol. Metab. 23 (8) :773-782 (2010)
Other Product Names
Vitamin D3 receptor, VDR,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, VDR, NR1I1
Tested Applications
WB
Protein ID
137617
Physical Properties
Liquid

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