VDR Antibody

• Background:

  This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.

• NCBI Gene ID:

  7421

• Swiss Prot:

  P11473

• Accession Number:

  P11473

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This VDR antibody is generated from rabbits immunized with a recombinant protein of human VDR.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  48 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  VDR

• NCBI Official Name:

  Vitamin D3 receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  An, B.S., et al. Mol. Cell. Biol. 30 (20) :4890-4900 (2010)

• Background Reference 02:

  Elnenaei, M.O., et al. Br. J. Nutr., 1-8 (2010) In press :

• Background Reference 03:

  Forghani, N., et al. J. Pediatr. Endocrinol. Metab. 23 (8) :843-850 (2010)

• Background Reference 04:

  Alvarez-Nava, F., et al. J. Pediatr. Endocrinol. Metab. 23 (8) :773-782 (2010)

• Other Product Names:

  Vitamin D3 receptor, VDR,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, VDR, NR1I1

• Tested Applications:

  WB

• Protein ID:

  137617

• Physical Properties:

  Liquid