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FH Antibody

CAT: 0223-59-859Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-859Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.
NCBI Gene ID
2271
Swiss Prot
P07954
Accession Number
P07954
Host
Rabbit
Reactivity
Human
Immunogen
This FH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-135 amino acids from the N-terminal region of human FH.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey, Mouse, Pig, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
55 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
FH
NCBI Official Name
Fumarate hydratase, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)
Background Reference 02
Allegri, G., et al. J. Inherit. Metab. Dis. 33 (4) :411-419 (2010)
Background Reference 03
Yogev, O., et al. PLoS Biol. (3), E1000328 (2010) :
Background Reference 04
Yang, Y., et al. Cancer Genet. Cytogenet. 196 (1) :45-55 (2010)
Other Product Names
Fumarate hydratase, mitochondrial, Fumarase, FH
Tested Applications
WB
Protein ID
1730117
Physical Properties
Liquid

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