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TRHR Antibody

CAT: 0223-59-858Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-858Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Thyrotropin-releasing hormone (TRH; MIM 275120), a small neuropeptide, is widely distributed throughout the central and peripheral nervous system as well as in extraneural tissues. The peptide is synthesized in the hypothalamus and transported by the portal vascular system to the anterior pituitary where it acts on thyrotropic and lactotropic cells to promote secretion of TSH and prolactin, respectively. Thyrotropin-releasing hormone receptor is a G protein-coupled receptor that activates the inositol phospholipid-calcium-protein kinase C transduction pathway upon the binding of TRH. The TRHR gene is expressed in the thyrotrope cells of the anterior pituitary.
NCBI Gene ID
7201
Swiss Prot
P34981
Accession Number
P34981
Host
Rabbit
Reactivity
Human
Immunogen
This TRHR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-238 amino acids from the Central region of human TRHR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Growth Factors
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
45 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TRHR
NCBI Official Name
Thyrotropin-releasing hormone receptor
NCBI Organism
Homo sapiens
Background Reference 01
Gehret, A.U., et al. Biochem. J. 428 (2) :235-245 (2010)
Background Reference 02
Gehret, A.U., et al. Mol. Pharmacol. 77 (2) :288-297 (2010)
Background Reference 03
Zhu, C.C., et al. J. Biol. Chem. 277 (31) :28228-28237 (2002)
Background Reference 04
Matre, V., et al. J. Neurochem. 72 (1) :40-50 (1999)
Other Product Names
Thyrotropin-releasing hormone receptor, TRH-R, Thyroliberin receptor, TRHR
Tested Applications
WB
Protein ID
464921
Physical Properties
Liquid

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