GNPTG Antibody

• Background:

  This gene encodes the gamma sunbunit of the N-acetylglucosamine-1-phosphotransferase complex. This hexameric complex, composed of alpha, beta and gamma subunits, catalyzes the first step in synthesis of a mannose 6-phosphate lysosomal recognition marker. This enzyme complex is necessary for targeting of lysosomal hydrolases to the lysosome. Mutations in the gene encoding the gamma subunit have been associated with mucolipidosis IIIC, also known as mucolipidosis III gamma.

• NCBI Gene ID:

  84572

• Swiss Prot:

  Q9UJJ9

• Accession Number:

  Q9UJJ9

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GNPTG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-296 amino acids from the C-terminal region of human GNPTG.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  34 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  GNPTG

• NCBI Official Name:

  N-acetylglucosamine-1-phosphotransferase subunit gamma

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kang, C., et al. N. Engl. J. Med. 362 (8) :677-685 (2010)

• Background Reference 02:

  Qian, Y., et al. J. Biol. Chem. 285 (5) :3360-3370 (2010)

• Background Reference 03:

  Pohl, S., et al. Am. J. Med. Genet.152A (1), 124-132 (2010) :

• Background Reference 04:

  Encarnacao, M., et al. Clin. Genet. 76 (1) :76-84 (2009)

• Other Product Names:

  N-acetylglucosamine-1-phosphotransferase subunit gamma, GlcNAc-1-phosphotransferase subunit gamma, UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma, GNPTG, C16orf27, GNPTAG

• Tested Applications:

  WB

• Physical Properties:

  Liquid