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FIG4 Antibody

CAT: 0223-59-674Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-674Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J.
NCBI Gene ID
9896
Swiss Prot
Q92562
Accession Number
Q92562
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This FIG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 846-874 amino acids from the C-terminal region of human FIG4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
104 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
FIG4
NCBI Official Name
Polyphosphoinositide phosphatase
NCBI Organism
Homo sapiens
Background Reference 01
Ikonomov, O.C., et al. J. Biol. Chem. 285 (35) :26760-26764 (2010)
Background Reference 02
Tsai, C.P., et al. Neurobiol. Aging (2010) In press :
Background Reference 03
Ikonomov, O.C., et al. J. Biol. Chem. 284 (51) :35794-35806 (2009)
Background Reference 04
Soranzo, N., et al. Nat. Genet. 41 (11) :1182-1190 (2009)
Other Product Names
Polyphosphoinositide phosphatase, 313-, Phosphatidylinositol 3,5-bisphosphate 5-phosphatase, SAC domain-containing protein 3, FIG4, KIAA0274, SAC3
Tested Applications
WB
Protein ID
2497367
Physical Properties
Liquid

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