FIG4 Antibody

• Background :

  The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J.

• NCBI Gene ID :

  9896

• Swiss Prot :

  Q92562

• Accession Number :

  Q92562

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  This FIG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 846-874 amino acids from the C-terminal region of human FIG4.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  104 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  FIG4

• NCBI Official Name :

  Polyphosphoinositide phosphatase

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Ikonomov, O.C., et al. J. Biol. Chem. 285 (35) :26760-26764 (2010)

• Background Reference 02 :

  Tsai, C.P., et al. Neurobiol. Aging (2010) In press :

• Background Reference 03 :

  Ikonomov, O.C., et al. J. Biol. Chem. 284 (51) :35794-35806 (2009)

• Background Reference 04 :

  Soranzo, N., et al. Nat. Genet. 41 (11) :1182-1190 (2009)

• Other Product Names :

  Polyphosphoinositide phosphatase, 313-, Phosphatidylinositol 3,5-bisphosphate 5-phosphatase, SAC domain-containing protein 3, FIG4, KIAA0274, SAC3

• Tested Applications :

  WB

• Protein ID :

  2497367

• Physical Properties :

  Liquid