Products for Research Use Only
RegisterLogin

NOG Antibody

CAT: 0223-59-664Size: 400 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-59-664Size:400 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4) . By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse.
NCBI Gene ID
9241
Swiss Prot
Q13253
Accession Number
Q13253
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This NOG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-111 amino acids from the Central region of human NOG.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
26 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NOG
NCBI Official Name
Noggin
NCBI Organism
Homo sapiens
Background Reference 01
Rudnik-Schoneborn, S., et al. Am. J. Med. Genet.152A (6), 1540-1544 (2010) :
Background Reference 02
Song, K., et al. J. Biol. Chem. 285 (16) :12169-12180 (2010)
Background Reference 03
Mangold, E., et al. Nat. Genet. 42 (1) :24-26 (2010)
Background Reference 04
Gutierrez, S.J., et al. Acta Odontol Latinoam 23 (1) :13-19 (2010)
Other Product Names
Noggin, NOG
Tested Applications
WB
Protein ID
15214099
Physical Properties
Liquid

Related Products

CatalogName
45-975Nogo 66 Receptor Antibody
45-975PNogo 66 Receptor Peptide
10-445Atinumab (RTN4/NOGO) - Research Grade Biosimilar
10-585Ozanezumab (RTN4/NOGO) - Research Grade Biosimilar
64-160WAS Antibody
60-596WAS Antibody
13-349WAS Antibody
62-828Neprilysin Antibody
61-580CAPZB Antibody
55-580HCG_2024410 Antibody

Alternative Products

CatalogName
MBS8529199-01H2B Antibody Antibody
MBS8513599-01CD11b Antibody Antibody
MBS850197-01Antibody to IGFBP2 Antibody
DF8746-01ASAP1 antibody Antibody
E36403ZNF98 Antibody Antibody
GWB-250026Lck antibody Antibody
E8M1007-4HSP60 Antibody Antibody
MBS9403836-01SZT2 Antibody Antibody
LSMab09882anti-Antibody^Polyclonal antibody control antibody
GWB-5C6547MAD1L1 antibody [9B10] Antibody

Popular Products