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OPTN Antibody

CAT: 0223-59-579Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-579Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
NCBI Gene ID
10133
Swiss Prot
Q96CV9
Accession Number
Q96CV9
Host
Rabbit
Reactivity
Human
Immunogen
This OPTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-96 amino acids from the Central region of human OPTN.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
66 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
OPTN
NCBI Official Name
Optineurin
NCBI Organism
Homo sapiens
Background Reference 01
McDonald, K.K., et al. J. Hum. Genet. 55 (10) :697-700 (2010)
Background Reference 02
Cheng, J.W., et al. Med. Sci. Monit. 16 (8), CR369-CR377 (2010) :
Background Reference 03
Albagha, O.M., et al. Nat. Genet. 42 (6) :520-524 (2010)
Background Reference 04
Maruyama, H., et al. Nature 465 (7295) :223-226 (2010)
Other Product Names
Optineurin, E3-147K-interacting protein, FIP-2, Huntingtin yeast partner L, Huntingtin-interacting protein 7, HIP-7, Huntingtin-interacting protein L, NEMO-related protein, Optic neuropathy-inducing protein, Transcription factor IIIA-interacting protein, TFIIIA-IntP, OPTN, FIP2, GLC1E, HIP7, HYPL, NRP
Tested Applications
WB
Protein ID
317373403
Physical Properties
Liquid

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