OPTN Antibody

• Background :

  This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

• NCBI Gene ID :

  10133

• Swiss Prot :

  Q96CV9

• Accession Number :

  Q96CV9

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This OPTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-96 amino acids from the Central region of human OPTN.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Immunology, Neuroscience, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  66 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  OPTN

• NCBI Official Name :

  Optineurin

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  McDonald, K.K., et al. J. Hum. Genet. 55 (10) :697-700 (2010)

• Background Reference 02 :

  Cheng, J.W., et al. Med. Sci. Monit. 16 (8), CR369-CR377 (2010) :

• Background Reference 03 :

  Albagha, O.M., et al. Nat. Genet. 42 (6) :520-524 (2010)

• Background Reference 04 :

  Maruyama, H., et al. Nature 465 (7295) :223-226 (2010)

• Other Product Names :

  Optineurin, E3-147K-interacting protein, FIP-2, Huntingtin yeast partner L, Huntingtin-interacting protein 7, HIP-7, Huntingtin-interacting protein L, NEMO-related protein, Optic neuropathy-inducing protein, Transcription factor IIIA-interacting protein, TFIIIA-IntP, OPTN, FIP2, GLC1E, HIP7, HYPL, NRP

• Tested Applications :

  WB

• Protein ID :

  317373403

• Physical Properties :

  Liquid