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MAEA Antibody

CAT: 0223-59-522Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-522Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene product mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. This protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Two immunologically related isoforms of erythroblast macrophage protein with apparent molecular weights of 33 kD and 36 kD were detected in macrophage membranes; this gene encodes the larger isoform. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.
NCBI Gene ID
10296
Swiss Prot
Q7L5Y9
Accession Number
Q7L5Y9
Host
Rabbit
Reactivity
Human
Immunogen
This MAEA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-42 amino acids from the N-terminal region of human MAEA.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Zebrafish, Monkey, Mouse, Rat, Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
45 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MAEA
NCBI Official Name
Macrophage erythroblast attacher
NCBI Organism
Homo sapiens
Background Reference 01
Kobayashi, N., et al. Gene 396 (2) :236-247 (2007)
Background Reference 02
Bala, S., et al. Biochem. Biophys. Res. Commun. 342 (4) :1040-1048 (2006)
Background Reference 03
Hanspal, M., et al. Blood 92 (8) :2940-2950 (1998)
Other Product Names
Macrophage erythroblast attacher, Cell proliferation-inducing gene 5 protein, Erythroblast macrophage protein, Human lung cancer oncogene 10 protein, HLC-10, MAEA, EMP
Tested Applications
WB
Protein ID
74754297
Physical Properties
Liquid

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