MAEA Antibody

• Background:

  This gene product mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. This protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Two immunologically related isoforms of erythroblast macrophage protein with apparent molecular weights of 33 kD and 36 kD were detected in macrophage membranes; this gene encodes the larger isoform. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.

• NCBI Gene ID:

  10296

• Swiss Prot:

  Q7L5Y9

• Accession Number:

  Q7L5Y9

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MAEA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-42 amino acids from the N-terminal region of human MAEA.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Zebrafish, Monkey, Mouse, Rat, Xenopus

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  45 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  MAEA

• NCBI Official Name:

  Macrophage erythroblast attacher

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kobayashi, N., et al. Gene 396 (2) :236-247 (2007)

• Background Reference 02:

  Bala, S., et al. Biochem. Biophys. Res. Commun. 342 (4) :1040-1048 (2006)

• Background Reference 03:

  Hanspal, M., et al. Blood 92 (8) :2940-2950 (1998)

• Other Product Names:

  Macrophage erythroblast attacher, Cell proliferation-inducing gene 5 protein, Erythroblast macrophage protein, Human lung cancer oncogene 10 protein, HLC-10, MAEA, EMP

• Tested Applications:

  WB

• Protein ID:

  74754297

• Physical Properties:

  Liquid