DR1 Antibody

• Background:

  This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.

• NCBI Gene ID:

  1810

• Swiss Prot:

  Q01658

• Accession Number:

  Q01658

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This DR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-112 amino acids from the Central region of human DR1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Chicken, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  19 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  DR1

• NCBI Official Name:

  Protein Dr1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Corneveaux, J.J., et al. Hum. Mol. Genet. 19 (16) :3295-3301 (2010)

• Background Reference 02:

  Kantidakis, T., et al. Nucleic Acids Res. 38 (4) :1228-1239 (2010)

• Background Reference 03:

  Albert, T.K., et al. Genome Biol. 11 (3), R33 (2010) :

• Background Reference 04:

  Kahle, J., et al. J. Biol. Chem. 284 (14) :9382-9393 (2009)

• Other Product Names:

  Protein Dr1, Down-regulator of transcription 1, Negative cofactor 2-beta, NC2-beta, TATA-binding protein-associated phosphoprotein, DR1

• Tested Applications:

  WB

• Protein ID:

  401162

• Physical Properties:

  Liquid