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DR1 Antibody

CAT: 0223-59-460Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-460Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
NCBI Gene ID
1810
Swiss Prot
Q01658
Accession Number
Q01658
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This DR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-112 amino acids from the Central region of human DR1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Chicken, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
19 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
DR1
NCBI Official Name
Protein Dr1
NCBI Organism
Homo sapiens
Background Reference 01
Corneveaux, J.J., et al. Hum. Mol. Genet. 19 (16) :3295-3301 (2010)
Background Reference 02
Kantidakis, T., et al. Nucleic Acids Res. 38 (4) :1228-1239 (2010)
Background Reference 03
Albert, T.K., et al. Genome Biol. 11 (3), R33 (2010) :
Background Reference 04
Kahle, J., et al. J. Biol. Chem. 284 (14) :9382-9393 (2009)
Other Product Names
Protein Dr1, Down-regulator of transcription 1, Negative cofactor 2-beta, NC2-beta, TATA-binding protein-associated phosphoprotein, DR1
Tested Applications
WB
Protein ID
401162
Physical Properties
Liquid

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